IntroductionThe main challenge for cancer therapy lies in immuno-suppressive tumor micro-environment.Reprogramming tumor-associated macrophages (TAMs) into an anti-tumor phenotype is a promising strategy.MethodsA comprehensive analysis by combing multi-regional single-cell, bulk and spatial transcriptome profiling with radiomics characterization wa
We present the development of a new algorithm which combines state-of-the-art energy-dispersive x-ray (EDX) spectroscopy theory and a suitable machine learning formulation for the hyperspectral unmixing of scanning transmission electron microscope EDX spectrum images.The algorithm is based on non-negative matrix factorization (NMF) incorporating a
Informed in hierarchical structure the factors of successful handball game, presents basic hipotese M Shoes of selection potencial handball players, but also very effective planning and programming necessary technology in the handball.If the handball as sport game take as totality integral system,then at define system,exepct of structural aspects,
Abstract Nowadays, Combine Harvesters are the most commonly used device for harvesting crops; as a result, a large Chainsaws amount of plant material and crop residue is concentrated into a narrow band of plant material that exits the combine, challenging the residue management task.This paper aims to develop a crop residue management machine that
In contrast to natural atoms, the potential energies for superconducting flux qubit (SFQ) circuits can be artificially controlled.When the inversion symmetry of the potential energy is broken, we find that multi-photon processes can coexist in multi-level SFQ circuits.Moreover, there are not only transverse but also longitudinal couplings between t